SUMMARY: The Medical Letter article on pantoprazole (July 24, 2000) stated that, according to Medical Letter consultants, pantoprazole tablets, like rabeprazole tablets (Aciphex), can be crushed and administered through a feeding tube. The article should have specified that this can only be done through a feeding tubes placed distal to the stomach because all proton pump inhibitors are inactivated by gastric acid. The labeling of pantoprazole and rabeprazole advises against crushing the tablets because oral administration is assumed and both drugs are formulated to prevent inactivation in the stomach.