Miudella (Sebela), a copper intrauterine device (IUD), has been approved by the FDA for prevention of pregnancy for up to 3 years. Miudella is the second copper IUD to be approved in the US; ParaGard, which contains more copper and is approved for up to 10 years of use, was approved in 1984. Four hormonal IUDs (Mirena, Liletta, Skyla, Kyleena) that release the progestin levonorgestrel are also available for pregnancy prevention (see Table 2).1
IUDs — IUDs are highly effective in preventing pregnancy....
RELEASE
The FDA has licensed mNEXSPIKE (Moderna), an mRNA vaccine, for prevention of COVID-19 in adults ≥65 years old and in persons 12-64 years old who have a condition that puts them at high risk for severe outcomes from COVID-19.1 Spikevax, the original Moderna mRNA COVID-19 vaccine, remains in production2; it is licensed for use in persons ≥12 years old and is available under an Emergency Use Authorization (EUA) for children 6 months to 11 years old.
THE NEW VACCINE — Spikevax and Comirnaty, the Pfizer/BioNTech mRNA COVID-19 vaccine, code for the whole spike protein of SARS-CoV-2. In contrast, mNEXSPIKE codes only for the N-terminal domain and the receptor-binding domain of the spike protein of the virus (Omicron variant JN.1); these domains are the targets of most effective anti-SARS-CoV-2 antibodies.3 The more targeted vaccine formulation allows for administration of a smaller mRNA …