Suzetrigine (Journavx) — A Sodium Channel Blocker for Acute Pain
March 3, 2025 (Issue: 1723)
The FDA has approved suzetrigine (Journavx –
Vertex), a selective sodium channel blocker, for oral
treatment of moderate to severe acute pain in adults.
Suzetrigine is the first sodium channel blocker to be
approved in the US for this...more
- Nonopioid drugs for pain. Med Lett Drugs Ther 2022; 64:33.
- Opioids for pain. Med Lett Drugs Ther 2022; 64:193.
- JD Osteen et al. Pharmacology and mechanism of action of suzetrigine, a potent and selective NaV1.8 pain signal inhibitor for the treatment of moderate to severe pain. Pain Ther 2025 January 8 (epub). doi:10.1007/s40122-024-00697-0
- T Bertoch et al. Randomized, placebo-controlled, phase 3 trials of suzetrigine, a non-opioid, pain signal inhibitor for treatment of acute pain after abdominoplasty or bunionectomy. American Society of Anesthesiologists (ASA) Anesthesiology Annual Meeting 2024. Philadelphia, PA. October 18-22, 2024. Available at: https://bit.ly/3Cuq2YH. Accessed February 12, 2025.
- Inhibitors and inducers of CYP enzymes, P-glycoprotein, and other transporters. Med Lett Drugs Ther 2023 January 25 (epub). Available at: www.medicalletter.org/downloads/CYP_ PGP_Tables.pdf.
- Approximate WAC. WAC = wholesaler acquisition cost or manufacturer’s published price to wholesalers; WAC represents a published catalogue or list price and may not represent an actual transactional price. Source: AnalySource® Monthly. February 5, 2025. Reprinted with permission by First Databank, Inc. All rights reserved. ©2025. www.fdbhealth.com/policies/drug-pricing-policy.
- DM Rind et al. Suzetrigine for acute pain: effectiveness and value. Evidence report. Institute for Clinical and Economic Review, February 5, 2025. Available at: https://bit.ly/4aUbe2f. Accessed February 12, 2025.
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